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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months’ duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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Later Period, Final Post-Operative Month Periods In the final post-operative month periods (Figure 17 and Figure 18), at the border of bone tissue and muscle, the control rats exhibited loose connective tissue and no close contact with muscle fibers and absent organized formation of bone tissue, but islands of bone tissue consistently appeared (Figure 17 and Figure 18)