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LDHA inhibition led to reduced lactate production, impaired aerobic glycolysis, decreased cell proliferation, and increased apoptosis in vitro , as well as significant tumor growth suppression in vivo (235)

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Sbraccia received payment of honoraria from Amryt Pharma (Chiesi), Boehringer Ingelheim, Eli Lilly, Novo Nordisk, Pfizer, and Roche, and as a member of advisory boards and payment of honoraria for lectures from Amryt Pharma (Chiesi), Eli Lilly and Novo Nordisk