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Food intake, VO 2 , VCO 2 , RER (VCO 2 /VO 2 ) and locomotor activity (beam breaks) were continuously monitored throughout the experiment

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In addition, a PET study showed that patients with ME/CFS exhibited significantly reduced whole-brain 5-HT1A receptor binding potential compared with healthy controls, including an approximately 23% reduction in the bilateral hippocampus, suggesting decreased receptor density or affinity