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prodrug of glycine Sarcosine (monomethylglycine) – endogenous glycine site agonist Serine (D-serine, L-serine) – endogenous glycine site agonist β-Alanine – endogenous glycine site agonist [78] Positive allosteric modulators Cerebrosterol – endogenous weak positive allosteric modulator Cholesterol – endogenous weak positive allosteric modulator Dehydroepiandrosterone (DHEA) – endogenous weak positive allosteric modulator Dehydroepiandrosterone sulfate (DHEA-S) – endogenous weak positive allosteric modulator Nebostinel (neboglamine) – synthetic positive allosteric modulator of the glycine site Pregnenolone sulfate – endogenous weak positive allosteric modulator Polyamines Spermidine – endogenous polyamine site agonist Spermine – endogenous polyamine site agonist Neramexane [edit] An example of memantine derivative is neramexane which was discovered by studying number of aminoalkyl cyclohexanes, with memantine as the template, as NMDA receptor antagonists

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Key findings highlight two main protective strategies: avoidance mechanisms involving root secretion regulation, cellular compartmentalization, efflux transport, and the other through chelation, antioxidant systems, and phytohormonal regulation in tolerance mechanisms