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Moreover, it was found that therapy with the multi-agonist improved leptin sensitivity in DIO mice (134)

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COA / Lab results Evidence: Preclinical Pros Selective, membrane-permeable NNMT inhibitor Raises intracellular NAD+ and SAM by blocking the methylation sink Reduced weight and fat mass in diet-induced obese mice Activates sirtuin pathways associated with metabolic health Cons Evidence entirely preclinical (cell/mouse)

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