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These include switching to a PPI with less dependence on the CYP2C19 enzyme, adding an H 2 RA at night, using alginate-based formulations, or, as a last resort, trialing a gamma-aminobutyric acid agonist like baclofen

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Notably, lycopene, a key component of the first pattern, is typically accompanied by colourless carotenoids like phytoene and phytofluene, as discussed by Dias et al [185]

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