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doi: 10.1016/j.cmet.2019.07.011 75 EssandohKLiYHuoJFanGC

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They can all express common surface markers such as tetraspanins (CD9, CD63, and CD81), heat shock proteins (HSP 60, HSP 70, and HSP 90), biogenesis-related proteins (Alix and TSG 101), and carry messenger RNA (mRNA), microRNAs (miRNA), and long non-coding RNAs (lncRNA), and DNA, and lipids (cholesterol and ceramide) ( One aspect of exosome functional heterogeneity is related to their parental cells as sharing similar contents during detachment