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Melatonin, for example, can enhance the expression of antioxidant enzymes by activating the Nuclear factor erythroid-derived 2-like 2 (NRF2) transcriptional pathway while simultaneously downregulating prooxidant enzymes such as lipoxygenases and nitric oxide synthases (NOS), which contribute to ROS production [129]

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In the liver, ethanol is primarily metabolized into acetaldehyde, a toxic intermediate, via oxidative pathways

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