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this indicates that PKC-mediated phosphorylation of S363 as well as T370 upon substance P receptor activation (Illing et al., 2014) are potentially involved in heterologous desensitization

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Phase II study of tivantinib and cetuximab in patients with KRAS wild-type metastatic colorectal cancer with acquired resistance to EGFR inhibitors and emergence of MET overexpression: lesson learned for future trials with EGFR/MET dual inhibition