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259 In addition, a dose escalation study of curcumin C3 capsules ranging from 450 to 3600 mg/day in 15 patients for 4 months showed reduced PGE 2 levels with high tolerability and no toxic events associated with treatment

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Markers of Circadian Phase The minimum of the core body temperature (CBTmin) and the dim light melatonin onset (DLMO) are two useful markers of the position of an individual’s circadian rhythms with respect to the external environment (i.e., time of day) (Box 26–2)