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In human osteosarcoma, enzyme levels were considerably higher both in cell lines and primary tumors (Uejima et al., 2011)

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Myeloid differentiation factor 2 (MD2) has been shown to be responsible for TLR4 activation and inflammation by directly binding to ox-LDL, which triggers the formation of the MD2/TLR4 complex and the proinflammatory TLR4-MyD88-NFκB cascade, opening a perspective for potential new therapeutic options for the treatment of atherosclerosis [70]