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10.1016/j.biopha.2013.04.005 78 JiangL.WangW.HeQ.WuY.LuZ.SunJ.et al (2017)

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Hyperglycemia promotes ROS production through multiple mechanisms, including mitochondrial overload, activation of the AGEs‐RAGE signaling pathway [47], and depletion of antioxidant capacity via the polyol pathway [48]