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According to another aspect of the present invention there is provided a method of therapeutically or prophylactically treating an individual against ischemic brain injury, the method comprising the step of administering to the individual a pharmaceutical composition to the individual, the pharmaceutical composition including a pharmaceutically acceptable carrier and a therapeutically or prophylactically effective amount of an antioxidant compound, the antioxidant compound having (a) a combination of molecular weight and membrane miscibility properties for permitting the compound to cross the blood brain barrier of the individual

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Without a published human dose-finding trial, whether any particular calculated dose is above, below, or at a therapeutic threshold is genuinely unknown