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It was also observed that GCN2 is activated in mice in response to treatment with asparaginase 99 , which is approved by the US Food and Drug Administration (FDA) for the treatment of acute lymphoblastic leukemia (ALL) and may deplete serum asparagine and glutamine 100–102

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[DOI] [PMC free article] [PubMed] [Google Scholar] 123.Sen S., Hendricks A.L., Cowan J.A