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Patients with creatinine clearances of 45, 50, and 80 mL/min had 65%, 54%, and 13% increases, respectively in pemetrexed total systemic exposure (AUC) compared to patients with creatinine clearance of 100 mL/min

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A Further Look at Sex and Gender Differences Beyond the possible role of hormones in vitiligo onset or progression as stated above, no significant sex differences have been reported so far as therapeutic response or disease severity is concerned [167]

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