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In addition, Ca 2+ signaling, chromatin changes, Wnt signaling, and RNA splicing also play an important role in the pathogenesis of these diseases

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The carboxyl group of the glycine part chelates with the two copper ions, with the hydroxyl oxygen binding to CuB at a distance of 2.82 Å and the carbonyl oxygen binding to CuA at a distance of 2.66 Å

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