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In mice treated with amoxicillin or ciprofloxacin, depletion of Lactobacillus reuteri (Firmicutes) led to reduced brain and serum GABA, downregulation of GABA-A receptors, and diminished 5-HT and DA, neurochemical changes that coincided with anxiety- and depression-like behaviors (Bibi et al., 2025)

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The fact that the symptoms were quickly relieved by the administration of a multivitamin containing vitamin B12 was also consistent with the characteristics of the disease