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The mechanism and result are similar to that of GSTP and JNK, in that GSTM1 sequesters ASK1 through complex formation and prevents its induction of the pro-apoptotic p38 and JNK portions of the MAPK signaling cascade

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Upon measuring grip strength, the researchers found that treatment on its own in sedentary mice increased grip strength by about 25%, compared to exercise alone increasing grip strength by about the same percentage