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DNA repair alone is not sufficient to determine cisplatin resistance in lung cancer cell lines One mechanism that could be responsible for the differential amount of DNA damage among the cell lines is cisplatin intracellular accumulation

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Although Compounds 1.62 and 1.64 lost activity for the GPx and/or GR enzymes responsible for the antioxidative effect and regeneration of the thiol group of GSH using other reductant sources, respectively, these compounds were still able to rescue the cell death of UVA irradiated cells as the neutralisation the free radicals produced by UVA irradiation could be achieved by other pathways