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Except for alleviating hepatic steatosis, SFN showed antidiabetic effects and ameliorated insulin resistance either by enhancing antioxidant capacity and improving FGF21 resistance in HFD and streptozotocin-induced type 2 diabetes or through activating AMPK/Nrf2-mediated antioxidative effect via inactivation of glutathione peroxidase 4 in HFD-induced insulin resistance in mice (Tian et al., 2021a

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Though the individual ingredients have been studied, this combination has not been well researched in large clinical trials on humans