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It's plausible that more copper peptide reaches systemic circulation via injection than topical application, but "reaches circulation" and "produces a proportionally larger effect" aren't the same claim, and GHK's short serum half-life complicates the simple version of this comparison considerably

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Technol Acta-Sci Prof J Chem Tech 15(1):69–79 [Google Scholar] He E, Li H, Li X, Wu X, Lei K, Diao Y (2022) Transdermal delivery of indirubin-loaded microemulsion gel: preparation, characterization and anti-psoriatic activity