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(Source) When this enzyme is present in great concentration within fat cells and is highly expressed, obesity is inevitable: βIn the study by Kannt and colleagues, NNMT expression is increased ~2-fold in subcutaneous and omental adipose tissue of type 2 diabetic subjects (men and women), compared to healthy controlsβ¦ Importantly, interventions that increase insulin sensitivity, such as exercise and bariatric surgery, also decreased expression of NNMT in adipose tissueβ For this reason alone, scientists have been interested in every possible method for inhibiting NNMT expression: βWe report that NNMT expression is increased in [white adipose tissue (WAT)] and liver of obese and diabetic mice