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SBIR/STTR is a weak fit when your product is a pure commercial play with no real federal mission tie-in, you cannot dedicate a senior technical person to the project at the time commitment SBA requires, your only goal is the Phase I check (~$250K with no follow-on plan), or you have already taken capital from foreign investors in a way that disqualifies you under the ownership rules

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It then plays a significant role in signalling tissue remodelling which removes damaged/scarred tissue and generates new, healthy tissue