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FFAs enter hepatocytes and are converted into triglycerides, promoting hepatic lipid deposition and increasing the risk of NAFLD (Vatner et al., 2015)。 The primary transcription factors involved in insulin-mediated fat synthesis are Upstream Stimulator Factor (USF) (Wang and Sul, 1997), sterol regulatory element-binding protein-1c (SREBP-1c) (Raghow et al., 2008), carbohydrate response element-binding protein (ChREBP) (Postic et al., 2007), and liver X receptor alpha (LXRα)