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Summary Keywords acute lymphoblastic leukemia, methotrexate, glutathione, metabolomics, drug resistance, arsenic trioxide, thioredoxin reductase Citation Canevarolo RR, Melo CPS, Cury NM, Artico LL, Corrêa JR, Lau YT, Mariano SS, Sudalagunta PR, Brandalise SR, Zeri ACM and Yunes JA (2022) Glutathione levels are associated with methotrexate resistance in acute lymphoblastic leukemia cell lines