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Ultimately, the main goal is a suppression of regulatory T cells and a generation of an effective effector T cell microenvironment by identifying the combination that is optimum in enhanced trafficking of the immune effector cells and their efficiency at the affected site

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However, upon HFD treatment, miR-21 was activated and promoted lipid accumulation and IR in hepatocytes through its influence on key metabolic enzymes involved in glucose and lipid metabolism [306]

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