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The authors concluded that a longer duration in the administration was desirable (210) and the same authors performed a second study with a longer treatment period (12 months) of folic acid supplementation evaluating the cognitive performance

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This effect may be attributed to the hydrogen atoms provided by the hydroxyl structure or the electron delocalization effect triggered by conjugation with the oxygen group, which leads to the scavenging of free radicals [51], and the hydroxyl structure of the B ring is the most important factor in determining the clearance of ROS and RNS compared to the A and C rings [54]