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Supporting this, a recent study demonstrated that high glucose conditions reduce DIO2 expression in retinal tissue, leading to decreased T4-to-T3 conversion and an increased T4/T3 ratio, ultimately lowering intracellular T3 levels [189]

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The most studied form is GHK-Cu , a naturally occurring copper peptide first identified in human plasma, saliva and urine, which is where scientists began studying its role in skin repair