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This was accompanied by the downregulation of nitric oxide synthase, cyclooxygenase-2, cyclin D1, and beta-catenin with reduced phosphorylation of PKCβ2 and NF-κB binding protein implicating the involvement of AR in mediating ACF formation [120]
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Since betaine and L-carnitine are both approved for use in complete and balanced diets, this study provides promising evidence for additional immune-supporting ingredients in pet food
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